There is no single main difference. The closest are real world physics, a vastly expanded and superior Galaxy, and 'proper' CPU usage (blocks don't use cpu, only systems do).

引用自 clop1000：

What is the main difference with the vanilla?

Check the description for a general overview.

引用自 nevryn：

The closest are real world physics

How are the 'physics' in RE any different than in Vanilla?

引用自 HurtfulPlayer97：

引用自 nevryn：

The closest are real world physics

How are the 'physics' in RE any different than in Vanilla?

It's the same physics, but blocks, devices, thrusters have better balanced stats.

and you can actually hit stuff with hand held weapons with the hitboxes in RE over vanilla haha