escort mission: breaks parts of the main game such as caravan and patrol behavior

hard labor uses strength: labor skill becomes useless, the actual mining becomes much slower and becomes a glorified strength training dummy

lockpick away: ruins lockpicking skill progression where originally you had to find chests of a suitable level to gain progress, now you can just AFK on the first level 100 lock you can find

improved slave locks: makes all the low tier prisoner shackles and cages have the highest quality locks on the planet for no reason, only rivaled by safes in ancient laboratories, also when combined with lockpick away lets you grind lockpicking forever on what's supposed to be easy low quality locks.

no player indicators for dark ui: i don't know why this mod even exists, kenshi is a map game. you're gonna click on the map quite often to order your character where to go. so it doesn't make much sense to be unable to see where you character is on the map.

some other mods have dialogue with lots of typos.

as for more opinionated takes:
native stylize just doesn't look good, the borders on everything don't go away completely even if you turn them off, and all the other effects only serve to make the game blurry and oversaturated.
inkarnate map imo doesn't fit the game and uses a lot of free inkarnate assets. it might look pretty but it has none of the clarity that the original map has. i actually prefer the vanilla map with or without area markers/borders, one lets you know where the areas are and what they are called, while on the other hand playing with an empty/base map gives you a better sense of progression because it's gonna be completely empty (while still showing what the world looks like on a surface) from the start and you're gonna discover it as you go.

i might add more to this thread as i gain more experience with this modpack.
mods i personally added to my install (at the bottom of optional but above autogenerated patch) that directly improve the game include: sensible spider range, white gorillo fur fix, no mining node stack limit, tribal hiver face paint, clouds and wind for deadlands and the pits.