This mod + Weapon Enchantments (Beta) = Frozen game and no keybinds work like open inventory or swap weapons.

You can click on UI elements and only interact with NPCs (not objects), which will open your inventory so you can access settings to exit world.

Tested this for a few hours with 63 other mods and this is 100% the mod that is causing the issue.

Going to list about half of these 63 mods tested just for reference of which mods are working with just fine with Polarities in solo play.
Able to have all 63 of these enabled at the same time and create a new world without issue.

Major Mods include: (Adds Biomes)
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Calamity
Secrets of the Shadows
Orchid Mod
Living World Mod
The Stars Above + Subworld Library(Dependency Mod)

Moderate content mods include:
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Archery Overhaul
Storm's Additions Mod
Whips and More
Expanded Weapons
Terraria Overhaul
Magic Storage
Fargo's Mutant Mod
Fargo's Best of Both Worlds

Lite content mods include:
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Assorted Crazy Things
AlchemistNPC Lite
Another RPG Mod
Apacchii's Classes: Reborn
Dungeons of Terraria [Early Access]
Liber Creaturarum
More Terra Weapons
MoreZenithItems
Ore Excavator
Terramania
Weapon Merge
Hero's Mod
Cheat Sheet
Quality of Life
LuiAFK Reborn

Basic Mods: (Info Panels, Textures, UI Changes)
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Atmospheric Torches
Lights and Shadows
Boss Cursor
Boss Checklist
Recipe Browser
Better Crafting Interface
Better Boss Health Bar
Calamity Rarities
Shop Expander
WikiThis
Colored Calamity Relics
Chester Opens Safe
Colored Damage Types
Dialogue Panel Rework

+26 other mostly basic type mods