Load order should not matter. Is this local game or a dedicated server? I've had some reports of inconsistent behavior with dedicated servers.

Local game.

Can you paste in the lines you modified in a comment here?

<?xml version="1.0" encoding="utf-16"?>
<ExpandedSettingsConfig xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<WorldSettingsModifier>
<SmallShipMaxSpeedMultiplier>-1.5</SmallShipMaxSpeedMultiplier>
<LargeShipMaxSpeedMultiplier>-1.4</LargeShipMaxSpeedMultiplier>
</WorldSettingsModifier>
<GeneralBlockModifiers>
<BlockDamageMultiplier>-1</BlockDamageMultiplier>
<BlockDeformationMultiplier>-1</BlockDeformationMultiplier>
<BlockConstructTimeMultiplier>-1</BlockConstructTimeMultiplier>
<BlockDeconstructTimeMultiplier>-1</BlockDeconstructTimeMultiplier>
</GeneralBlockModifiers>
<MiningModifiers>
<OreDetectorMaxRangeMultiplier>-10</OreDetectorMaxRangeMultiplier>
</MiningModifiers>
<PowerModifiers>
<SolarPowerMultiplier>-2</SolarPowerMultiplier>
<WindPowerMultiplier>-2</WindPowerMultiplier>
<HydrogenPowerMultiplier>-2</HydrogenPowerMultiplier>
<ReactorPowerMultiplier>-2</ReactorPowerMultiplier>
<BatteryCapacityMultiplier>-2</BatteryCapacityMultiplier>
<BatteryMaxOutputMultiplier>-2</BatteryMaxOutputMultiplier>
<BatteryMaxInputMultiplier>-2</BatteryMaxInputMultiplier>
</PowerModifiers>
<ThrusterModifiers>
<AtmoThrusterThrustMultiplier>-2</AtmoThrusterThrustMultiplier>
<AtmoThrusterPowerMultiplier>-2</AtmoThrusterPowerMultiplier>
<HydroThrusterThrustMultiplier>-2</HydroThrusterThrustMultiplier>
<HydroThrusterFuelEfficiencyMultiplier>-1</HydroThrusterFuelEfficiencyMultiplier>
<IonThrusterThrustMultiplier>-2</IonThrusterThrustMultiplier>
<IonThrusterPowerMultiplier>-1</IonThrusterPowerMultiplier>
</ThrusterModifiers>
<WheelModifiers>
<WheelPropulsionMultiplier>-1</WheelPropulsionMultiplier>
<WheelAxleFrictionMultiplier>-1</WheelAxleFrictionMultiplier>
<WheelMaxPowerRequirementMultiplier>-1</WheelMaxPowerRequirementMultiplier>
<WheelIdlePowerRequirementMultiplier>-1</WheelIdlePowerRequirementMultiplier>
<WheelMinOffsetMultiplier>-1</WheelMinOffsetMultiplier>
<WheelMaxOffsetMultiplier>-1</WheelMaxOffsetMultiplier>
<WheelMaxSteeringAngleMultiplier>-1</WheelMaxSteeringAngleMultiplier>
<WheelSteeringSpeedMultiplier>-1</WheelSteeringSpeedMultiplier>
</WheelModifiers>
<BlockToolsModifiers>
<WelderBlockRangeMultiplier>-4</WelderBlockRangeMultiplier>
<GrinderBlockRangeMultiplier>-4</GrinderBlockRangeMultiplier>
<DrillBlockRangeMultiplier>-4</DrillBlockRangeMultiplier>
</BlockToolsModifiers>
<H2O2BlockModifiers>
<OxygenFarmMaxYieldMultiplier>-2</OxygenFarmMaxYieldMultiplier>
<IceToO2ConversionMultiplier>-2</IceToO2ConversionMultiplier>
<IceToH2ConversionMultiplier>-2</IceToH2ConversionMultiplier>
</H2O2BlockModifiers>
<CommsBlockModifiers>
<BeaconMaxRangeMultiplier>-1</BeaconMaxRangeMultiplier>
<BeaconMaxPowerDrainMultiplier>-1</BeaconMaxPowerDrainMultiplier>
<AntennaMaxRangeMultiplier>-1</AntennaMaxRangeMultiplier>
</CommsBlockModifiers>
<LightBlocksModifiers>
<PointLightMaxRangeMultiplier>-1</PointLightMaxRangeMultiplier>
<SpotlightMaxRangeMultplier>-1</SpotlightMaxRangeMultplier>
<SpotlightConeAngleMultiplier>-1</SpotlightConeAngleMultiplier>
</LightBlocksModifiers>
<SpaceBlockModifiers>
<GravityGeneratorMaxRangeMultiplier>-1</GravityGeneratorMaxRangeMultiplier>
<GravityGeneratorMaxStrengthMultiplier>-1</GravityGeneratorMaxStrengthMultiplier>
<SphericalGravityGeneratorMaxPowerRequirementMultiplier>-1</SphericalGravityGeneratorMaxPowerRequirementMultiplier>
<ArtificialMassMaxMassMultiplier>-1</ArtificialMassMaxMassMultiplier>
<JumpDrivePowerNeededForJumpMultiplier>-1</JumpDrivePowerNeededForJumpMultiplier>
<JumpDrivePowerDrawMultiplier>-1</JumpDrivePowerDrawMultiplier>
<JumpDriveMaxWeightMultiplier>-1</JumpDriveMaxWeightMultiplier>
<JumpDriveMaxDistanceMultiplier>-1</JumpDriveMaxDistanceMultiplier>
</SpaceBlockModifiers>
<CharacterModifiers>
<PlayerHealthMultiplier>-2</PlayerHealthMultiplier>
<PlayerInventoryMultiplier>-50</PlayerInventoryMultiplier>
<OxygenConsumptionMultiplier>-1</OxygenConsumptionMultiplier>
<JetpackHydrogenConsumptionMultiplier>-1</JetpackHydrogenConsumptionMultiplier>
<JetpackStrengthMultiplier>-1.5</JetpackStrengthMultiplier>
<JetpackSlowdownMultiplier>-2</JetpackSlowdownMultiplier>
<SuitConsumptionInTemperatureExtremeMultiplier>-1</SuitConsumptionInTemperatureExtremeMultiplier>
</CharacterModifiers>
<WeaponsModifiers>
<HandheldWeaponsDamageMultiplier>-1</HandheldWeaponsDamageMultiplier>
<SmallCalliberDamageMultiplier>-1</SmallCalliberDamageMultiplier>
<LargeCalliberDamageMultiplier>-1</LargeCalliberDamageMultiplier>
<MissileDamageMultiplier>-1</MissileDamageMultiplier>
<MissileRadiusMultiplier>-1</MissileRadiusMultiplier>
<WarheadDamageMultiplier>-1</WarheadDamageMultiplier>
</WeaponsModifiers>
<VisualModifers>
<ModifyInteractHighlights>false</ModifyInteractHighlights>
<InteractHighlightLineThicknessMultiplier>-1</InteractHighlightLineThicknessMultiplier>
<InteractHighlightColor>
<X>255</X>
<Y>255</Y>
<Z>0</Z>
</InteractHighlightColor>
<InteractAccessDeniedHighlightColor>
<X>255</X>
<Y>0</Y>
<Z>0</Z>
</InteractAccessDeniedHighlightColor>
</VisualModifers>
</ExpandedSettingsConfig>

I play with RivalAI and EEM and MEE and lots of other difficulty increasing mods, bringing harder enemy ships into my singleplayer game. Even hunting me down. So I wanted to get an edge with inventory size and other modifiers. Speed myself up because, well, I tend to develop slowly and get destroyed since I don't rush to build a defensible base first.

A lot of the values you modified still have a minus sign in front of them. All of the values are set to be -1 by default so that they are disabled, but they will need to be positive numbers to actually do anything.

Oh... duh.

In that case I need to lower some numbers, hahaha. I kept increasing them to see if they were changing things.

Glad it was an easy fix. Let me know if there are any more issues. =P