When I first downloaded this route, it worked great. Now, whenever I try to open the route, the route opens but the selected locomotive is in a derailed state, so I cannot do anything. I've tried changing locos and starting points, but nothing works.

It sounds like you might have to remove the route and then re download it. Often times TS will mess up and seemingly delete certain random files within a route, the only way I've figured out how to fix it is simply removing then re-downloading the route. If you don't want to do that, another thing I'd recommend is verifying the integrity of your game cache. You can do this by going to library>Train Simulator>Properties>Local Files>Verify the Integrity of Game Cache. This can take a while depending on the size of your TS collection.

What quick drive destinations were set, and what kind of consist where you using? I need to check and make sure it works for me, in case this isn't a case of TS's poor file management and a bigger problem within the route.

I tried removing and re-downloading the route awhile back but didn't help. The latest Quick Drive starting point was BN Moscow N with a destination of BN Pullman Main N. However, I have had the same problem using other consists and starting points.

I'll verify the integrity of my game cache and see if that helps.

Thank you.

Verifying the integrity of my game cache revealed one missing file which was reacquired. All is well now. Thank you!

That's great to hear! If anything else goes wrong let me know and I'd be happy to try and help.

Thanks!