I don't know if unload is the right word. Let me give you an example. I have Sword of Omens weapon mod that lets me craft the, well, Sword of Omens. I crafted the weapon and saved my game.

I only just started playing the game today, all the mods are new, I played from a new game. I save the game and quit to desktop. I start the game back up, load a save, and the Sword of Omens that I crafted is not in my hand, not in my inventory, it is gone. This is happening to all of my mods in one form or another. A quest mod I have keeps telling me I got the quest, even though I'm simply loading a save. I have all the load file boxes checked in the data files section when the Launcher loads in, and I wait for it to check all the files to make sure their up to date before clicking play.

The only thing that I know for a fact works, is deleting all of the items from the Data Files section, exiting the Launcher, and then they work for some reason. I am not going to do that every time I want to play, so I need a real solution, please and thank you.

Note: I AM NOT USING SKYRIM SPECIAL EDITION I AM USING ORIGINAL SKYRIM WITH THE THREE DLCS. I'm saying this because all of the solution I do keep finding are for Special Edition which I am not using. In fact I tried to uncheck the load boxes for the DLCs but that just crashed the game outright. Only thing I haven't tried is to uninstall and reinstall the game with the DLCs. This will require me to get rid of one of the mods but this is not a big deal.

Update: okay, so after right after writing all this, I Uninstalled and reinstalled the game, this time on my computers main hard drive. I had it installed on a external hard drive I have plugged into my computer. And now all of a sudden it works. I've had no problems with the saves. For now anyway. I'm in no rush to push my luck. Can someone explain whats going on here?