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All runes are unlockable by completing the stated challenge
Gebo = Interacts with any machine or beggar in the room. Donates 7 coins to donation machines, plays beggars 6 times, plays blood machines 4 times, plays other machines 5 times. Machines and beggars have an increased chance to pay out or explode, even paying out at only one play (Bloody Mary)
Kenaz = Poisons all enemies in a room (Scat Man)
Fehu = Half of monsters in a room get the Midas Touch effect for 5 seconds (Cantripped)
Othala = Gives Isaac a random item that he already holds (Seeing Double)
Ingwaz = Opens all chests in a room (Baptism by Fire)
Sowilo = Revives all enemies killed in a room (Red Redemption)


