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Cthulhus Spirit

Cthulhu's Spirit is a passive item that appears in secret rooms, red chests, and dungeons (mob trap rooms). This item gives Isaac the ability to fly, and it leaves a blue creep under your feet wherever you go. This creep damages enemies and gives them fear. Also, Cthulhu's Spirit gives every enemy temporary confusion upon entering a room. However, this item gives no stat changes.

Code and sprites - blinkafrootable
Concept - Coolmonster