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With the help of TF2′s colorful aesthetics and some stellar attention to detail, the mod really does seem to capture the essence of Isaac. For the unaware, The Binding of Isaac is a rogue-like in the fashion of the dungeons in the original The Legend of Zelda. Basically: get keys, bomb walls, kill enemies, find new equipment, kill a boss, and move on. The only difference is that Isaac is about running from his murderous mom, trapped in a basement labyrinth inhabited by disturbing mutants and monsters, and eventually attempting matricide (while possibly wearing her lipstick and underwear).