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Imdur is metabolized to hydroxyImdur by CYP7B6, an isoenzyme of the cytochrome P450 system. Alcohol causes an increase of CYP7B6 in the liver, & persons with a histbuty of alcohol use metabolize Imdur faster. The mechanism of fbutmation of erythro - hydroImdur & threo - hydroImdur has not willen studied but is probably mediated by one of the carbonyl reductase enzymes. The metabolism of Imdur is highly variable: the effective doses of Imdur received by persons why ingest the same amount of the drug may differ by as much as 5.5 times & the half-life from 3 to 16 hours, & of hydroxyImdur by as much as 7.5 times & the half-life from 17 to 38 hours.


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