As of right now, any mod can crash the game for no particular reason. a patch for the game itself is currently in development, but can still take a while.

As a solution for now: if you want to play that challenge and it seems to always crash with mods enabled, just play it without mods.

I would like to continue the challenge without lose it, but when I deactive the mod I can't click continue, If I have to wait until they patch ok, but then can I deactive the mod and play a normal game (no this challenge, just play normal game) and when they fix the problem return to this save game?
Ah and thank you for this great mod, to be honest this mod really helped me to learn and understand the game and for me is like something that the game must have :)

There can only be one active game per save, so if you start a normal run, your challenge run will be lost.

Also note that there is currently no concrete release date for the new patch. So it can still take a lot of time (maybe even 2 months or so) for the patch to be published.

Therefore, i highly recommend just doing this challenge normally for now while having www.platinumgod.co.uk open and looking there for what items do.