System: Mac
Icon scale: 2560*1600
single player mode

After place first card, the whole game came to unresponsive, no response on clicking anything, only thing I can do is press ESC.

Would you be able to check if anything unusual shows up in the logs? They can be found in the `tModloader-Logs` folder under tML's install dir (found by right clicking tModLoader in the library, then Manage -> Browse local files)

my log: https://docs.google.com/document/d/1iTtXx-niFUptxWRVtDoXMeANbKUVBIqF0bR12d0GQC0/edit?usp=sharing

Thanks for sending that over. It looks like that screen is also high DPI and high resolution, I suspect there is some issue with the UI interaction code in the mod for high resolution screens given that. I am not quite sure how to proceed with fixing that but will keep this thread updated.

I am also running into this problem, I am able to interact twice or more, but only rarely. I am unable to play the mod fully (I believe that it is also because I am on mac.) Hope this gets fixed soon.