maybe its possible to make an unlock item that makes isaac spawn a ring of salt whenever he takes damage?
call it like "salty blood" or smthn

Technology Minus
"Gunpowder tears"
Low tears in exchange for explosions right in front of you when you shoot

Unlock: Mother as Tainted Edith

-An item similar to 'Mask of Infamy' that has a 30-40% chance to turn incoming bullets into stationary obstacles that work like bone spurs. Maybe with an aura similar to 'Dad's Ring' or 'The Soul'
No idea for a name, but maybe something that references tears being salty

-An Item that grants immunity to creep and grants certain tear-effects or stat-ups, depending on the type of creep the character is standing in.
Some reference to salt absorbing liquid, maybe

- Salt Lamp, "lick it"
grants a censer-like aura, but will get permanently smaller on taking damage (inverse-salvation), making it useless after 8-12 or so times. Obvs shouldn't proc on stuff like blood donation machines, only on enemy damage

- Dry Tears, active, 6-charge, works like 'Isaac's Tears'
Starts with character damage x2, but decreases in damage after each use. Damage resets after going to the next room

Just came to my mind:
-White Knight (Chess Piece as Sprite), active Item with charge-time and double use like Anima Sola
Gives Isaac the ability to jump like Edith with all advantages and drawbacks. On first use shows the crosshair which can be moved via wasd/lstick. On 2nd use performs the jump.
-Black Tower (Chess Piece as Sprite), active Item, same as above
Basically the Tainted Edith equivalent, allowing Isaac to dash with immunity to contact damage etc.. Either dash in the direction Isaac is currently moving on use, or freeze Isaac in place and use T-Edith's crosshair to perform a dash, idk