Probably the dumb/broken overdose mechanic. I currently have a character that will die the next time I play them due to this stupid mechanic. The big problem being that I just had 3 energy drinks and seemingly wasn't even warned of an overdose as far as I can tell. Because sickness was building up I then took a lemongrass which seemingly made things _even worse_ very quickly. It's complete nonsense. Didn't take any drugs (not even vitamins, which I hear are also broken), didn't smoke, didn't take any alcohol.