This is how i manage enemy dificulty in the campaign i am making right now:

1. You have to make a new character ( this is because right now it is not possible to get players current karma level.)
2. Track all the karma the player gets in the game with help of an int varibale.
3. Spawn enemies dynamicly on maps through regions and teleports, i have a pool of enemies outside of map, going from level 1 to 6. This is how i split it up:
Spawn Lv1 with karma 34 - 40
Lv2: 41 - 72
Lv3: 73- 104
Lv4: 105 - 136
Lv5: 137 - 168
Lv6: > 169

Same i do for shops: Low shops for 0 - 72 karma, mid shops for 73 - 136, high shops for > 137

Hope this helps somehow.

Its food for thought. Thanks.

frankly all you need is to look at adding cusom weapons that fit with the damage pools of the original game. a pistol that does 1-3 dmg critting for 6 dmg would be a good starting weapon.

That is an option, but then we can't really allow people more flexibility in how they play (ie extra weapon choices, other character classes, etc) without making it too easy for them. I'd much rather upscale the stats to fit with the new system.

Isn't it simple to add a karma level question at the beginning? I like using my 300+ karma character that I beat the main campaign and some other campaigns with, couldn't you just have a question at the beginning that lets the game adjust according to my players karma?

Adding a question at the beginning is easy enough. I plan on having a "settings" scene once everything is all set so people can configure things like spawn rate, enable/disable quests, enable/disable "real" conversations, etc.
I'll add a difficulty setting option to the planned list. I think I can make it work by adding a "calibrate" function (to every scene with enemies) that is called whenever an enemy spawns and ups their power level. The other option is to multiple the number of spawners, creating one for every karma level...