Had the same thing happen. The settings file for Immersive Taming is corrupted. Deleting that settings file and redoing it from fresh slate fixed it for me. No other workaround that I've found thus far. Annoying having to redo all my custom taming stats, but hey, better than not being able to modify settings ever again.

Ongoing issue here too. On a hosted dedicated server, acct is tagged as an admin. Adjusted settings and was force kicked from the server. File purge (as noted above) does not work at all. Settings does not save and trying to decode the .sav file for the mod (to see if I can set some settings offline) is like trying to read hieroglyphics.

Following actions were performed.
1. Performed radial > reset IT Settings (kick)
2. Performed radial > adjust IT settings (kick)
3. Performed radial > Check for new dinos (not kicked)
4. Purged file while server is offline (regenerates at reboot, kick while performing item 2)
5. Purge file after server boot and retried (kick)
6. Purge file after opening settings, made changes, closed (kick)
7. Had a weird idea, ran the command line options normally for SP/Local (like the goggles in chem class, they do nothing).

This might be a bit of a stretch, but, could it be ignoring the presence of an admin manipulating the settings?