Thanks to Sanction for making his video, where I got the base idea.

• This method worked for me every time last 3 tries on each scenario.
  
• You should read the whole guide before start to get the whole idea.
  
• Travelling part is most important and you need to be very fast, every milisecond counts.
  
• Sometimes you might want to shuffle some traits in the midgame if you need more infectivity or slow the research. This requires a basic understanding of the game mechanics.
  
• If you don't have good understanding of the game mechanics, you might want to reload the game every time you mutate different symptom than you need.

GENETIC CODE

• Brawler
  
• Budget Bat
  
• Aerocyte (Teracyte for Lava God)
  
• Urbophile
  
• Mad Scientist

DIFFICULTY

• Normal

STARTING COUNTRY

• Start in CANADA (close to USA)

EVOLVE

• Shadow Blessing
  
• Lair
  
• Theriantropy
  
• Blood Gift
  
• Dark Cloud

Now you can start travelling with your vampire using it's active ability that cost 0 DNA.

• play on NORMAL SPEED
  
• always travel to the closest country
  
• always use the shortest path
  
• after the vampire lands wait for first wave of people getting infected and PAUSE
  
• then plan the next journey and UNPAUSE
  
• land in EVERY uninfected country or in country that has less than 2k infected people
  
• whenever you have enough DNA, use them immediately
  (BUT remember you need some for the next lair establishment)

TRAVEL PATH

• move to USA and establish a FIRST LAIR there
  
• move to MEXICO
  
• CARRIBEAN and evolve Shadow Trail
  
• CENTRAL AMERICA
  
• COLOMBIA and evolve Droplets 1
  
• PERU
  
• BOLIVIA
  
• ARGENTINA
  
• BRAZIL and evolve Travel Speed 1
  
• travel to WEST AFRICA and establish a SECOND LAIR there
  If you forgot to save DNA for the lair, you can set it up later in Central Africa.

You can save your game here.

Now you have the idea how to travel, so there is quick version for your next travel plan.
MOROCCO - ALGERIA - LYBIA - CENTRAL AFRICA - ANGOLA - SOUTH AFRICA - BOTSWANA - ZIMBABWE - EAST AFRICA - MADAGASCAR - SUDAN - EGYPT - SAUDI ARABIA

During the flights you should be evolving some traits.
Fomites 1 - Corrupted Air - Droplets 2 - Fomites 2 - Shadow Portal

Then follow the same strategy in Asia going one country at a time up to RUSSIA.
Set up a THIRD LAIR in Russia and save your game.

Then go down to Oceania, Australia (set up the LAST LAIR) and New Zealand and then go up infecting last Asia countries on east side all the way to Japan/Korea.

Your game should look like this:







Now it is time to TELEPORT back to RUSSIA close to the borders of EUROPE.

This should took you about 6,5 months to come to this point. If it's more than 7 months you were too slow travelling through countries and you should reload the last save.

If you are good to go, save the game and move on to the next phase.

Now it is time to infect rest of the world.

Follow the exact same strategy and infect Europe, while evolving symptoms to help us spread the plague.

TRAVEL:
Start in Scandinavian countries, then go down to Center, SouthWest, then GB, Island and finally Greenland.

EVOLVE:

• Nocturnal
  
• Anaemia
  
• Pallor
  
• Weeping Sores
  
• Hyperdontia
  
• Jugular Bite
  
• SHADOW SLAVES

Now TELEPORT back to USA and spend few seconds here and in CANADA while waiting for DNA points to evolve Blood Rage. Both countries should have at least 1 milion people infected.

Now your game should look like this:





Templar bases are set up at this point. If you feel that more than 1 base is too far from one of your lairs reload the last save. Usually each base is in one continent, most troubles are with South America or NorthEast Europe, since they are very far from our lairs. Most countries of Europe and Asia are easily accessible from Russian borders.

This should took you about 8 months to come to this point. If it's more than 8,5 months you were too slow and you should try again from the last save.

If you are good to go, save the game and move on to the next part.

Here comes the hard part.

• always prioritize destroying labs and defending lairs
  
• if you are attacking base and a lab or drone pops up, go destroy that immediately
  
• if you don't manage to destroy lab before it goes blue, reload the last save
  
• heal yourself in lair after or during battling templars
  
• dont waste time staying somewhere unless you are healing yourself
  
• Pause-Travel-Unpause tactics is still very viable

EVOLVE:

• Blood Rage
  (From this point, every time you stay in some place, use the Blood Rage ability in that country, it greatly increases amount of people getting infected. You should be doing it in the least infected countries, but don't go too far from where you want to continue your work.)
  
• Adrenal Surge
  
• Dark Infiltration and destroy 1st BASE (farthest one)
  
• Malignant Pigmentation
  
• Lair Healing 1
  
• Shadow Blades and destroy 2nd BASE (next farthest one)
  (Now it is about 1 year from the start of the game.)
  
• Hypersensitivity
  
• Dark Pustules
  
• Latent Adaptation
  
• Muscular Hypotrophy
  
• Masticatory Tension
  
• Lair Healing 2
  You should be battling last 2 close templar bases simultaneously now, get them both to 5-10% life and then destroy one, teleport close to the other one and destroy it before the planes from the other one land in. 3rd and 4th bases are now destroyed.

Now you are done with the templars and your game looks like this:

Now it is time to finish the world off and deal with those research contributors.

• Travel to the countries that are not fully infected yet and deploy BLOOD RAGE in that country.
  
• Prioritize the countries that are key research contributors.
  (This is visible on the right side of the world screen.)
  
• You can travel to the next country when current country is 90% infected.

You should still be getting DNA points, so use the rest on the following:

• Blood Sacrifice 1
  
• Dermal Calcification
  
• Blood Sacrifice 2

As soon as the whole world has been infected, thanks to shadow slaves - YOU WIN.

You should be done

• in around 500 days
  
• approximately 20% of cure progress
  
• scoring 65k+ points