To force Ghostbusters: The Video Game to have Anti-Aliasing, go to your "AppData" directory by putting in %appdata% into a Windows window (you can get one up by going to your Windows menu and then clicking a directory on the menu) and then putting %appdata% into the Window's location text box which is at the top of the Window (it will most likely be in "Roaming" when accessing it first so back out of this directory into the root directory), then go to "Local" and get "GHOSTBUSTERS (tm)," after this open up "settings.ini" with a text editor such as Notepad and set antiAliasMultipleX and antiAliasMultipleY to "2" and you're done.

This will make the game look much better. AA is what the game needs.

NOTE #1: Folder and directory are interchangable i.e. they mean the same thing.
NOTE #2: SSAO is also available but is buggy so don't bother with it.

Have fun!