This guide might not work for all people out there with Windows 10, but 2 friends of mine tried it and it worked perfectly.

Don't worry, you can't mess up your game files by following this tutorial.

Yes, you must install manually Game for Windows Live in order to get the game running. In order to get that follow the next steps:

• Be sure that you have a newest version of GFWL.
  
• You can download it from http://www.xbox.com/en-US/live/pc/DownloadClient (Just click the link and you will see blue download button)
  
• After the installation is completed, you don't have to login or create a Microsoft account, just leave it on login screen.
  
• After that you can try to start a game, it should work without further tweaks.

Make sure that you set HDR mode at Launcher options. (Screen Effects)

Then run the game.

If that doesn't work, you might want to try other guides as well, but this one worked for several people on Windows 10 x64 Build 10130.

Thank you for reading this guide and make sure to leave a comment and tell me if this guide worked or not for you.

Fallout 3 is a masterpiece game and it works quite well on Windows 10. If you have some question, don't hesitate to ask!

Have fun playing the game.