Strictly following everything on here for your first playthrough isn't necessary, as your New Game+ (NG+) run afterwards should allow you to catch up on anything you missed the first time. You simply need to aim for the True Ending, which should be easily achievable through normal gameplay.

Here's some information regarding the difficulty setting scale as well (with Normal difficult as the baseline 1.0x):

One thing worth mentioning before you begin Death end re;Quest 2 (DER;Q2) is that there's a Costume DLC for Shina which adds additional dialogue for her at the camp, and during victory screens. You will need to equip the costume once she joins, or else you won't get to hear the additional content. While the extra content is nice and develops Shina a little further, it doesn't impact the story very much, so don't feel that it's a necessary purchase for the full experience.

Lastly, the limited edition of DER;Q2 comes with a 48 page short novel titled "Death end re;Quest 1.5" which acts as the connection between the original game and the sequel. I'm going to assume you've already beaten the original game, because the novel definitely contains important spoilers related to it. As for DER;Q2, you can definitely read it before playing (no real spoilers), but I suggest finishing NG+ beforehand to contextualize some of the more vague story elements.

Excluding today, midday events are considered side stories that can be skipped. Furthermore, certain actions that you take throughout the story can affect the appearance of some events, so keep that in mind while playing.

• ? - Women’s Dormitory 2F Hallway 2
  
• ? - Cafeteria
  
• ? - Women’s Dormitory Gate

If you ever get lost or confused about the directions, feel free to reference the Area Maps section and use the treasure chest items as a guide for reorienting yourself. And remember to always interact with save points when you come across them, as that'll come in handy in the future.

From your starting point, you can find a Patch 1.0 to your west and slightly north, just before the red wall barrier. Return to the nearby save point and interact with the ringing phone booth... On NG+, that grants you access to the Ao Oni minigame, and the Pain Area (though you can only access the minigame currently).

Head towards the event point, and then interact with the glowing PC to hack it. This is Mai's Bug Skill, and you'll be using it frequently to reveal hidden things.

Go through the false wall, and at the intersection, head southwest first for another Patch 1.0 before going northeast to find another PC. Hack it, and don't forget to pick up the Osiris Balm just north of the PC.

Pass through this second false wall and go east. Keep an eye on your left side while moving through this alleyway, and you'll find Dorm Area Key A just before the event point. Before triggering the event, go southeast behind the train car for a Panacea, and use the key you just got to unlock the green barrier behind you for the future.

Now you can go to the event point, which will put you in your first battle.

• Betty - Cafeteria
  
• Abigail - Women’s Dormitory 1F Hallway 1
  
• Victorie - Women’s Dormitory 2F Hallway 2

Women's Dormitory - Center
Enemies will now spawn on the map, so take some time to review the Character Flash Drive Skills section to make combat easier on yourself for the future.

Head towards Women's Dormitory - Outskirts by returning to where you fought the 2 Cursed Golems yesterday. During the loading screen, you hear a surprise creepy groan, but don't worry, this is the only time in the game that it'll happen.

Side note, you may have accidentally stumbled across this already, but if you swing your weapon at windows and cars around this map, it'll play an effect and you'll get a "Breaking Objects" tutorial. I'm pretty sure this was an abandoned or forgotten feature that never got used, but for some reason was left in the game.

Women's Dormitory - Outskirts
From here, head along the path until you see a PC. Ignore the PC for now, as just around the corner (north then west) is a chest with 300 Eni.

Now go back to hack the PC, and head east through the false wall. When you reach the street facing a car and are given a choice between going north or south, head south first to pick up a Speed Bracelet before progressing north.

There's an Apprentice Ring for you to grab before you hit a red barrier, and to the west next to another PC is Mai's Headband. Hack the PC and head north through yet another false wall, continuing until you reach the save point with a Patch 1.0 next to it.

Head south of the save point until you find a Silver Hatchet at the end of the road. Now you can go to event point, west of the save point, to trigger the boss fight.

• Marie - Women’s Dormitory 1F Hallway 2
  
• Christina - Cafeteria
  
• Paula - Women’s Dormitory 1F Hallway 1
  
• Pick - Women’s Dormitory 2F Stairs
  
• Molly - Women’s Dormitory 2F Hallway 2
  
• Chitsuba - Women’s Dormitory 2F Hallway 2

Rottie joins your party, and you can now perform Super Knockback, Super Knock Blow, plus enter Glitch Mode. Super Knockback & Super Knock Blow are basically quick time events that help you get in extra damage during combat by amplifying the knockback on enemies, and unlike the original DER;Q, Glitch Mode no longer has any drawbacks (still need to maintain above 80% corruption, but you no longer die at 100% corruption).

Women's Dormitory - Center
Head back to Women's Dormitory - Outskirts; next to where the green barrier was (unlocked using the Dorm Area Key A), there's a new treasure chest with Rottie's Ribbon that you can pick up along the way.

Women's Dormitory - Outskirts
Just north of entering the outskirts is a new treasure chest containing an Osiris Balm, pick it up and head towards the event point.

Here, you're introduced to Dark Shadows. Getting caught by them leads to an instant Game Over, but luckily they're easy to deal with. In this case, you have to run back where you came for another event, but during normal gameplay you can just kite and run past them instead of running away (they despawn after some time). You can also get into a battle with a mob to immediately despawn them.

Go back to where you found the 300 Eni treasure chest beyond the computer, and you'll find the red barrier is now gone. Walk further in to find an Orichalcum Ring.

Return to the computer and head east through the false wall to find a Mettle Bracelet next to the car on the north-south intersection street, then move to the event point for a boss battle. A Dark Shadow might spawn, but you can just ignore it and trigger the event.

• Charlie - Women's Dormitory 1F Hallway 2
  
• Chitsuba - Women's Dormitory 1F Hallway 2
  
• Colette - Cafeteria
  
• Mercy - Women's Dormitory 2F Hallway 1
  
• Mary - Residential Area
  
• Makoto - Downtown
  
• Elizabeth - Main Street

Women's Dormitory - Center
Head back to Women's Dormitory - Outskirts.

Women's Dormitory - Outskirts
Go to the event point, and head all the way to the east to the next event point to be introduced to Rottie's Bug Skill.

After jumping the golden barrier, head in the direction of the save point and you'll pass by another golden barrier after going through a false wall. Hop over this second golden barrier, hack the nearby PC to the south and go through the false wall to the east to find an AX-3000. To the south of this treasure chest is the event point for the boss.

Dialogue Choice:
Take the USB stick, and...

• Insert it. Continue
  
• Don't insert it. Death End

• Victorie - Women’s Dormitory 1F Hallway 1
  
• Pick - Women’s Dormitory 2F Hallway 2
  
• Abigail - Women’s Dormitory 2F Dormroom 2
  
• Cera - Back Alley

Time for your introduction to missions, which are side quests that you can complete for some decent equipments and consumables, and bonus episodes that are exclusively available during NG+. These can be picked up at the camp when interacting with the bell in front of the tent, and you'll want to remember to do that at the start of every chapter (don't forget to turn them in after completing them as well). For more detail on completing them, refer to the Mission List section.

Chapter 3 Missions:

• Tale of Triumph I
  
• Collection Mission 1
  
• Shopping Mission 1
  
• Item Collection Mission 1 (NG+)

Women's Dormitory - Center
Collect your missions for this chapter. You won't be able to complete them all this chapter, but make sure everything is done by chapter 4 or you might miss optional episodes during NG+.

New parts of the map have opened up for you to explore. Before heading to the event point, go east into the alleyway just slightly north of the phone booth to find a Patch 1.0, then south for a Patch 2.0 next to the red barrier.

Now go west then south, heading towards the event point. You should find an Osiris Balm in the southeast corner, then go west some more. At the intersection where the event point is just south of you, continue west to find a Panacea beside a car, and head northwest (north of the red barrier blocking Residential Area - Center) for a Patch 1.0 in the corner, then south for 450 Eni.

With the new treasure chests collected, return to the event point and proceed to the next area.

Shopping District - Fountain Area
Head north and check the save point to the west of the fountain before going east. You'll find a Patch 2.0 at the end of the east path with a couple of floating platforms for Rottie to jump up, and an SP Medicine 2.0 at the top.

Drop down and head north until you reach a red barrier, where you'll head west instead. Hack the PC and go through the false wall to the north. The dead end to the north contains an Osiris Balm, grab that and continue down the path to the east. You'll jump past a golden barrier and continue onwards, finding an 800 Eni treasure chest right next to the transition zone for Shopping District - Celebrity Arcade.

Shopping District - Celebrity Arcade
The path is fairly straightforward for quite some time, don't forget to pick up the Patch 2.0 along the road, hack the PC to reveal the false wall, and grab the Pearl Hair Ornament next to a red barrier.

At the intersection where there's a dead end to your west, and a golden barrier to your east, grab the 1000 Eni at the dead end before jumping the barrier. Continue along the path and you'll find an Osiris Balm beside the save point, which is also next to the transition zone for Mountain Path - Town Outskirts.

Mountain Path - Town Outskirts
Check the save point to the north, and head east until the intersection where you can go northeast, or southeast. Take the southeast route and grab the SP Medicine 1.0 at the end of it, then head back to the intersection and go the northeast route.

There'll be another split in the road forming a triangle - a northeast route, a southeast route, and a road connecting the two routes with a floating platform for Rottie to jump up. First, head down the southeast route and pick up the Patch 2.0. Next, jump up to the floating platform for Mountain Area Key A. Finally, head up the hill to the north and use the key to remove the green barrier.

From here, there's three roads to take: west, north, and east. They all kind of loop back to each other, and whichever route you first take usually spawns a Dark Shadow, so go west to trigger the spawn, then take the east path. Jump up the floating platform for a Conjury Bracelet, then continue along north, ignoring west route intersection that leads to the north road. Pick up the Patch 2.0 in the bushes, and you'll arrive at the transition zone for Mountain Path - Summit Outskirts. Ignore this for now and head southwest towards the bug skill point for another platform to jump up, which contains a Mighty Ring. Finally, just a little ways southeast of here is a treasure chest with an Osiris Balm. With that collected, you can now head to the next area.

Mountain Path - Summit Outskirts
Stop by the save point and grab the Patch 2.0 to the west of it, then head east to an open space. To the northwest of this area is an Osiris Balm, and on the floating platform is a Seil Hook. Go further east and you'll find a Dark Shadow spawn near another floating platform, which has Mountain Area Key B. Pick up the key and head to the event point to fight the next boss.

• Mary - Cafeteria
  
• Charlie - Cafeteria
  
• Victorie - Women’s Dormitory 1F Stairs
  
• Christina - Women’s Dormitory 1F Stairs
  
• Paula - Women’s Dormitory 1F Hallway 2

Women's Dormitory - Center
Head to the event point.

Dialogue Choice:
The house is on fire.

• It may spread to the church. Sarah will die, can trigger Death End later
  
• It won't spread. Anne & Sarah survive, Death End inaccessible

You can now use any save point to teleport between previously accessed save points. Use it to teleport to "Mountain Path - Southern Summit Outskirts."

Mountain Path - Summit Outskirts
Go to the event point and Liliana will join your party.

Northwest from where you fought the boss yesterday is a green barrier you can use the Mountain Area Key B you picked up yesterday. Before doing that, head southwest into the area where the Dark Shadow spawns and pick up the two treasure chests containing a Panacea and Dual Elise.

Head towards the event point, and you'll be introduced to Liliana's Bug Skill, which lets you break white barriers as long as you have a Curse Ball.

East of where you are is a chest with a Turing Star, which is what you need for Shopping Mission 1. Head northwest next to find Liliana's Glasses and Smiting Nail Bat, followed by going slightly east, then far north (between the green and white barrier) to find a Curse Ball. Use this Curse Ball to unlock the white barrier you passed by to the east, and collect Mountain Area Key C. There is also a Killing Filler here for "Tale of Triumph I" mission if you haven't completed it yet.

Head back west and use the key on the green barrier. Check the save point and turn in everything except for "Collection Mission 1" which will be done during Chapter 4.

Go to the event point to progress the story and fight the next boss. Depending on your dialogue choice at the church earlier, you may get another one here...

Dialogue Choice:
Liliana seems winded.

• Wait for Liliana. Death End
  
• Keep going. Continue

Actions have consequences. If you chose the dialogue choice which led to Sarah dying, you will no longer be able to view any future sub story episodes involving Anne and Sarah. These types of missable episodes will be marked with a strikethrough, as seen below.

• Sarah - Women's Dormitory 1F Hallway 1
  
• Anne - Women's Dormitory 1F Hallway 2
  
• Marie - Cafeteria
  
• Rottie - Mai & Rottie’s Room
  
• Molly - Women’s Dormitory 2F Stairs
  
• Betty - Women’s Dormitory 2F Hallway 1

Chapter 4 Missions:

• Tale of Triumph II
  
• Collection Mission 2
  
• Drop Mission 1
  
• Small Boss Mission 1
  
• Item Collection Mission 2 (NG+)

Women's Dormitory - Center
Teleport to "Mountain Path - Northern Summit Outskirts" for a quick trip.

Mountain Path - Summit Outskirts
Head west towards where you previously fought the boss, and then south (a Dark Shadow might spawn). At the end of the dead end are two chests, one with an SP Medicine 1.0, and one with Drinblue (for Collection Mission 1).

Now head back to the save point to pick up this chapter's missions, turn in last chapter's mission, and teleport back to "Women's Dormitory Area - Center."

Women's Dormitory - Center
Go southeast and head through the transition zone for Tourist Area - Souvenir Street.

Tourist Area - Souvenir Street
Grab the save point just east of your starting point, then head south. Hack the PC and go through the false wall to pick up an Osiris Balm, and a Curse Ball on top of a floating platform.

Return to the save point and go north this time. Before breaking the white barrier, stop by the dead end to the east of it for a Patch 3.0.

Beyond the white barrier is another Curse Ball, which you'll easily spot by looking at the key icon on the map. Use it to break the second white barrier just a little further north for a Sapphire Hair Ornament, and the dead end to the east contains an SP Medicine 1.0. Once you've collected these items, head west to the transition zone for Lakeshore Area - Nature Trail.

Lakeshore Area - Nature Trail
As usual, stop by the save point first.

Head into the northeast path first to pick up a Patch 3.0, then go to the north path just west of this one for a Talisman Ring on top of a floating platform (be careful avoiding the Dark Shadow that spawns).

Now head south towards two more dead ends. The southeast one contains a Curse Ball, as indicated by the event key item icon, and the southwest one contains an SP Medicine 1.0.

Break the white barrier blocking your path to the west, and pick up another SP Medicine 1.0 to the south end, before continuing further west through a narrow path. To the south on the map is another Curse Ball, grab that and continue along the north path.

This long winded road leading to a bridge has a few Dark Shadow spawn locations, and you'll pass by three treasure chests containing a Panacea, an Osiris Balm, and a Ptella Tree. Grab them and cross the bridge.

Break the white barrier just east of the bridge and grab the Phantasm Bangle there, then head to the event point to finish the search for Chitsuba.

• Betty - Women's Dormitory 1F Hallway 1
  
• Chitsuba - Cafeteria
  
• Liliana - Mai & Rottie's Room
  
• Makoto - Woods

Women's Dormitory - Center
Teleport to "Lakeshore Area - Nature Trail."

Lakeshore Area - Nature Trail
Go back to where you were yesterday. To the northeast is a Curse Ball that you can use on the nearby white barrier to your west. Go in and pick up the Holy Earrings before heading back northeast through the transition zone to Lakeshore Area - Lake Outskirts.

Lakeshore Area - Lake Outskirts
Stop by the save point and head west, towards the southwest corner, for a Patch 3.0. To the north of this place, behind the Dark Shadow, is the miniboss Tylerfais which you'll need to defeat for Small Boss Mission 1, and behind the miniboss to the north is a treasure chest with Raoul-Ville.

Return to the save point and head northeast now. Pick up the Curse Ball and use it to break the white barrier just southeast of where you found it.

You'll come across a split path with one leading north, and the other east. They both lead to the same place, but only the east one contains a treasure chest that you can access by jumping up the floating platform. It contains a Ptella-Makin Alma.

Heading north, a Dark Shadow might spawn, and around that area you'll find 1000 Eni. Grab it and continue northwest-ish. You'll pass by a white barrier and a green barrier, both of which you can't unlock yet.

You'll reach a split in the road that leads north and south. The north dead end contains a Curse Ball, and an SP Medicine 1.0, while the south one holds Lakeshore Area Key A on top of the floating platform. Once you collected them, head back to the white barrier you passed by earlier for a Nail Bat, and then proceed through the green barrier with the key.

Grab the Osiris Balm just north of you, and head through the event point.

There's a save point to the south, and up the hill to the east of it is the second Ptella Tree you need for Collection Mission 2.

If you're on NG+, make sure you've completed all your missions, as the event point to the southwest of this save point is the boss fight which ends this chapter.

The boss name is Succubus, but in Japanese it's actually 悲恋鬼 which more accurately can be translated as "Tragic Love Demon," giving a bit more context...

Dialogue Choice:
This monster...

• Finish it off. Continue
  
• Get closer.. Death End

Sub Story events that are New Game+ exclusive will now start showing up, and some are locked behind mission clears, so that's why you have to clear them before the end of every chapter starting with Chapter 4.

• Rottie - Women's Dormitory Entrance
  
• Anne - Inner Yard
  
• Pick - Women's Dormitory 2F Hallway 2
  
• Shina (NG+ Mission) - Mai & Rottie's Room
  
• Natsuo (NG+) - Church

Chapter 5 Missions:

• Tale of Triumph III
  
• Collection Mission 3
  
• Shopping Mission 2
  
• Drop Mission 2
  
• Item Collection Mission 3 (NG+)

Women's Dormitory - Center
If you enabled Shina's Maid Outfit DLC, you can now equip it, which allows the real Shina to participate in victory screen dialogues and allows Mai to talk to her at the camp.

Remember to slot in someone to replace Liliana, who was removed from your party.

Collect your missions for this chapter, then teleport to "Women's Dormitory - Outskirts."

Women's Dormitory - Outskirts
Head east and hack the PC beside a couple enemies, then run north through the false wall. A Dark Shadow will spawn behind you as you approach the PC, so make it quick, or fight an enemy to despawn it. Just north and a little east of the false wall is a floating platform for Rottie to jump up and claim Dorm Area Key B, followed by an SP Medicine 1.0 further east.

Head back to the save point, and go west to use the key on the green barrier. Don't forget to pick up the Osiris Balm right next to the transition zone to "Rural Area - Pasture."

Rural Area - Pasture
The Rural Area has quite a lot of empty space to wander about, so you may need to reorient yourself by referencing the Area Maps section.

Stop by the save point just ahead, and check out the PC marked by the bug skill point just west of you on the map. This reveals a hidden treasure chest containing a Vitas Bracelet in the field across from you (marked by the red glow), which is located almost directly north of the save point. Grab that and head back to the house where the PC was. On the other side of the house is a Patch 3.0.

Now head west into the field behind the house, and you'll find a few bug skill points around the center. Hack the PC next to the barn first to reveal two hidden chests, a Mage's Ring on the southwest corner of the field, and Rural Area Key B on one of the floating platforms. There's also Liliana's Scarf on a different floating platform nearby, so grab that as well.

Leave this field and head west to another field. In the southwest corner, you should find a Dark Material for Shopping Mission 2.

Head directly north from the bug skill points near the floating platforms until you see another bug skill point (a PC). Hack it to reveal a Sapphire Hair Ornament just south of you, and an Amethystomagear northeast of you in the field. Go north of the PC you just hacked, just beyond the house, and grab the AR Code Patch as well.

You can finally head towards the event point, and use the key you got earlier to reach it.

Dialogue Choice:
Abigail...

• Search just in case. Abigail survives, can trigger Death End later
  
• She may have returned. Abigail will die, Death End inaccessible & end night early

Depending on your decision, you may or may not be able to continue exploring. I will assume you can, but if you can't, you just have to do the following the next day instead...

Rural Area - Pasture
Head west past the bridge and go south until you see the bridge leading to a red barrier; there's a Panacea Code next to it beside the fence.

Go back to the bridge where you viewed the event point earlier, and head north into the field. In the northeast corner is a Neo-Whip Spider, 1 of 3 needed for Collection Mission 3.

Now head to the transition zone to Rural Area - Watershed.

Rural Area - Watershed
Check the save point, and hack the PC to your east to reveal two hidden treasure chests for tomorrow night, then go to the event point.

Dialogue Choice:
The mysterious symbols?

• Head straight back. Death End
  
• Look for the passcode. Continue

• Sarah - Women's Dormitory 1F Hallway 1
  
• Paula - Cafeteria
  
• Midra (NG+ MIssion) - Women's Dormitory 1F Hallway 1
  
• Mary - Main Street

Women's Dormitory - Center
Teleport to "Rural Area - Southern Watershed Area."

Rural Area - Watershed
Head north until you can enter the field to the right of the PC you hacked yesterday. Grab Grandou Alma from the field's northwest chest next to the tractor, and Cerberus Fasuli from the southeast chest next to a hay bale.

Go back north to the main road and head eastward along it. You should see two bug skill points, which are both PCs. Hack them both to reveal two chests. The hidden chest to the field in the south contains Rural Area Key A, and the hidden chest to the east next to the PC contains Reaper Manacross. There's also an Osiris Balm in the grass just north of the same Reaper Manacross PC, just to the east of the green barrier bridge.

Use the key you picked up on the green barrier, and stop by the save point.

To your northeast, near the enemy, is an SP Medicine 1.0 hiding in the grass. Head towards the house with the event point next to it, and loop around to the back of it (northeast corner) to find the second Neo-Whip Spider.

DO NOT trigger the event point yet. Head east along the road and cross the bridge. Immediately to the north is Dias, the miniboss you have to defeat for Tale of Triumph III. Defeat it and grab the 2000 Eni chest nearby to the north.

Continue east, up the hill where there's a bug skill point, and jump up to the platform to get an Animal Bat. Then head down, and following the road where an enemy is roaming, there should be a chest with the final Neo-Whip Spider (southwest part of that area).

Return to the save point and hand in all your missions. Now you can go to the event point for the boss battle.

• Colette - Cafeteria
  
• Liliana - Mai & Rottie's Room
  
• Abigail - Women's Dormitory 2F Dormroom 2
  
• Cera - Cafeteria
  
• Molly - Residential Area
  
• Pick - Cafeteria
  
• Elizabeth - Downtown
  
• Mercy - Church
  
• Shina (NG+ Mission) - Downtown

Chapter 6 Missions:

• Tale of Triumph IV
  
• Collection Mission 4
  
• Drop Mission 3
  
• Small Boss Mission 2
  
• Item Collection Mission 4 (NG+)

Women's Dormitory - Center
Grab your missions and run to the transition zone to Shopping District - Fountain Area.

Shopping District - Fountain Area
Head to the nearby save point, as there's an AR Code Patch next to it.

Pull up your map, and you should see an event key item around the northwest area that you've never been to. Head towards there, and you'll find two dead ends: one to the south with a Curse Ball; and one two the east with a Red Quartz.

Now backtrack towards the white barrier you ignored earlier. Right before reaching the white barrier, there's a dead end to the west that contains SP Medicine 2.0. Go through the white barrier after to get a Charm Bracelet.

Run back through the false wall and head towards Shopping District - Celebrity Arcade. Pay attention, as you'll pass by two treasure chests, one with a Paladin's Ring, and the other with an Osiris Balm.

When you arrive before the green barrier you'll realize that it requires a code to unlock. Hack the PC next to it to discover the lock code: 37564.

Pick up the Valor Earrings just beyond the barrier, and enter the transition zone to Shopping District - Celebrity Arcade.

Shopping District - Celebrity Arcade
Head straight east towards where there used to be a red barrier, and there'll be two dead ends: one leading north with a Macabre Cleaver, and the other leading east with an Osiris Balm 2.0.

Pull up your map and take the same route you took the last time you were here until you reach the first white barrier - there'll be a Mysterious Hairball around the southwest dead end, a Patch 2.0 next to the red barrier, an SP Medicine 2.0 and Curse Ball just north of the white barrier, and an AX-9000 to the far east dead end.

Before you break this first white barrier, fight the enemy Face Terror nearby, as it's actually hiding Valmetro, the miniboss that drops a Shadow Dragon's Scale for Small Boss Mission 2.

Now you can head through the first white barrier and continue towards the event point.

When you're near the event point, you'll find a Curse Ball, and a chest with a Viostar LT. Pick them up, and head back where you came, towards the second white barrier that you ignored earlier. Use the Curse Ball to bypass it, and you'll receive an Amelum Bat.

Head to the green barrier west of the event point and hack the nearby PC for the lock code: 48614.

Turn in all your missions, then trigger the event point.

• Anne - Cafeteria
  
• Christina - Women's Dormitory 1F Stairs
  
• Shizu (NG+ Mission) - Women's Dormitory 1F Hallways 2
  
• Cera - Empty Room
  
• Iris (NG+ Mission) - Mai & Rottie's Room
  
• Sarah - Downtown
  
• Makoto - Main Street

Women's Dormitory - Center
Teleport to "Shopping District - Fountain Area."

Shopping District - Fountain Area
Head to the event point, and then teleport to "Shopping District - Celebrity Arcade."

Shopping District - Celebrity Arcade
Head to the event point.

Dialogue Choice:
What should I do...?

• Call out. Death End
  
• Keep quiet and watch. Continue

If you're on NG+, you should save before this next dialogue choice in order to quickly reload after viewing all the Chapter 7 and 8 episodes related to this choice.

Dialogue Choice:
Who do I send it to?

• Lily Yurisa Yamamura will appear later
  
• Al Hinata Morikubo will appear later
  
• Clea Kaede Hizumi will appear later
  
• Lucil Svetlana Amou will appear later
  
• Celica Chloe Aaron will appear later

And now, instead of a boss fight, you have to deal with up to 5 waves of mobs...

Dialogue Choice:
Run away? Or fight?

• Run away. Elizabeth and Mercy will die, skip remaining 4 waves
  
• Fight! Battle another wave of mobs

Dialogue Choice:
Run away? Or fight?

• Run away. Elizabeth and Mercy will die, skip remaining 3 waves
  
• I'll still fight! Battle another wave of mobs

Dialogue Choice:
Run away? Or fight?

• Run away. Elizabeth and Mercy will die, skip remaining 2 waves
  
• Keep fighting! Battle another wave of mobs

Dialogue Choice:
Run away? Or fight?

• Run away. Elizabeth and Mercy will die, skip final wave
  
• Keep fighting! Battle another wave of mobs

• Marie - Women's Dormitory 1F Hallway 1
  
• Charlie - Women's Dormitory Entrance
  
• Elizabeth - Women's Dormitory 1F Hallway 2
  
• Bishop - Women's Dormitory Entrance
  
• Rottie - Women's Dormitory 2F Stairs
  
• Mercy - Women's Dormitory 2F Stairs
  
• Sumika (NG+) - ???

Chapter 7 Missions:

• Tale of Triumph V
  
• Collection Mission 5
  
• Shopping Mission 3
  
• Drop Mission 4
  
• Item Collection Mission 5 (NG+)

Women's Dormitory - Center
Grab your missions and go to the southwest transition zone to Tourist Area - Souvenir Street.

Tourist Area - Souvenir Street
Head to the save point just east of you to start, and go north.

Hack the PC for the lock code: 93864.

Just slightly northwest of the PC is a chest with Pure Earrings hiding in the grass next to a rock pile. Head further north to pick up an Osiris Balm from the northern dead end, and an SP Medicine 2.0 from the dead end to its east nearby.

Now head south towards the green barrier on the map, and unlock it with the lock code you found earlier.

Continue along the path, grabbing the Patch 4.0 and Cerberus Ring along the southeast waters.

In the next area where you find a PC, pick up the Passable Enze in the northeast corner next to the broken car, then go hack the PC to reveal the hidden chest containing a Curse Ball to the east dead end.

Break the white barrier just north of the PC, and follow along the path, heading towards the event key item on the map. Pick up the Curse Ball, and go north. There's a Gold Hope for Shopping Mission 3 along the waters near some trash before the path turns west.

You'll eventually reach the transition zone to Tourist Area - Sightseeing Street, with a white barrier to your south. Break the white barrier and pick up the Knight's Bracelet, then continue to the next map.

Tourist Area - Sightseeing Street
Look to your left at the start to find an Osiris Balm, then head north and grab another Osiris Balm sitting just east of the save point.

Continue west from the save point, and the dead end has a Ragged Claw for Collection Mission 5 next to some cars.

Proceed northwest and loop around south towards the event key item on your map. There's a PC for you to hack, and an SP Medicine 2.0 to pick up next to it. Head through the false wall, and take the Curse Ball and Kideto Hook there.

Break the white barrier you passed by earlier, and head west until the road splits north and south. Go south first to pick up the Osiris Balm, then go north.

Stop by the save point, and pick up the chest with 4000 Eni directly north of it. Now head northeast to the event point to end the night.

• Colette - Cafeteria
  
• Liliana - Women's Dormitory 2F Hallway 2
  
• Mercy - Women's Dormitory 2F Hallway 2
  
• Shina's Friend (5 Variants NG+) - Downtown

Women's Dormitory - Center
Teleport to "Tourist Area - Sightseeing Street West."

Tourist Area - Sightseeing Street
Return to where you were yesterday, and head to the northwest corner dead end for an AR Code Patch, then turn around and hack the PC for the lock code: 62614.

Head east towards the dead end for your second Ragged Claw, then unlock the green barrier to the south with the code.

To the northeast of this new area, next to the car and water, is a chest with Messai Reize. Grab it, and head to the event point to your south.

Pick up the Remote Buster next to the tombstone after the event, and take the nearest west path to your south towards the center of the map. You'll find the miniboss Airdones there for Tale of Triumph V.

After defeating Airdones, head to the event key item on your map just to the north for a Curse Ball, and the final Ragged Claw in a chest next to it.

Go back east, and take the south path towards the white barrier for an SP Medicine 2.0.

Now head towards the west save point on your map by taking the path through the center of the map. You'll pass by a chest with Pole Gear before dropping down.

Turn in all your missions, and if you're in NG+, this is your last chance to complete the Pain Area if you haven't done so already. Teleport back to "Women's Dormitory - Center" and interact with the phone booth to do so.

Once you're ready, go to the event point to fight the next boss.

Dialogue Choice:
Should I ask Headmistress Midra...

• For the truth. Death End
  
• Don't say anything. Continue

On NG+, you can reload to the 02/02 save after the Cross-Examination main story event that takes place here, as that's the last unique entry episode in the Episode Chart for that dialogue choice. Although the "Devil's Hand Approaches" episode has some differences as well, the game doesn't have separate entries for each one.

• Lydia (NG+ Mission) - ???
  
• Rin (NG+ Mission) - Downtown
  
• Rin (NG+ Mission) - Main Street
  
• Natsuo (NG+ Mission) - Women's Dormitory Gate

Depending on whether you saved Abigail, either Abigail or Cera will talk to Mai and the girls tonight. These are separate entries in the Episode Chart.

Dialogue Choice:
Rottie...

• Rest for a bit. Death End on the next event
  
• There's no time. Continue

Women's Dormitory - Center
Head towards the event point in front of the dormitory.

Chapter 8 Missions:

• Tale of Triumph VI
  
• Collection Mission 6
  
• Small Boss Mission 3
  
• Item Collection Mission 6 (NG+)

Collect your missions for this chapter, then flee southwest to the transition zone to "Residential Area - Center."

Residential Area - Center
Head north to the save point, and pick up the AR Code Patch 2.0 next to it.

Head east and when the path leads south, go to the northeast corner (along the fake red barrier) for a Steady Knight Blade.

Continue along until the road splits north and south. Head south to pick up Rottie's Hair Ornament, and jump up the floating platform for Residential Area Key A.

Now head north, unlock the green barrier with the key, and continue north until you find a PC. Hack it, and pick up the Rune Mana Cross just a little further north, before heading through the false wall.

Grab the Giant's Ring along the path to the northeast, and the Magician's Bracelet that's on the floating platform a little further down the line.

Hack the PC that you'll come across and get the lock code: 99924.

Unlock the green barrier with the code, and head to Residental Area - Outskirts.

Residential Area - Outskirts
Stop by the save point and follow the road west, ignoring the green barrier for now.

At the top of the hill where the road splits northwest and south is the miniboss Meteonotos, which you'll need to kill for Small Boss Mission 3.

Take down Meteonotos, and head south. Grab the SP Medicine 2.0 at the dead end, and jump up the floating platform for an Andit-Ville.

Head back to the crossroad, and this time go northwest. Have Rottie jump you to the floating PC, and hack it to reveal the hidden chest containing Residential Area Key B just below you. Pick up the key, and head to the dead end to your west for a Kil-Makin Alma.

Now run back to the green barrier and proceed further after unlocking it with the key.

You'll be greeted with a bunch of enemies along the street, and a Dark Shadow will spawn behind you. You can jump up to the rows of floating platforms above, but don't miss the Material Blower treasure chest on the floor.

At the west end, you'll see a PC for you to hack. Before doing that, turn your camera and look at the broken white car to the left among the rubble for a chest containing a Bugged Whip Spider, which you need for Collection Mission 6.

Go hack the PC now for the lock code: 46645.

When you get near the green barrier, a Dark Shadow will spawn really close to you, so be careful.

Stop by the save point and head directly east for an Osiris Balm, then north (near the event point) for an SP Medicine 2.0. Finally, head to the northwest corner of the map for Chaos Phonspear.

If you're in NG+, this is your last chance to complete the Ao Oni minigame if you haven't done it already. Teleport back to "Women's Dormitory - Center" and interact with the phone booth to do so.

Once you've turned in your missions and are ready, go to the event point for a boss battle.

This chapter consists solely of unmissable story content with no dialogue options.

Brink of Life and Death - Entrance
Teleporting has been disabled, and there are no new missions.

From the save point, head east and hack the PC to reveal a hidden chest. Go north and you'll pass by an SP Medicine 3.0 (watch your right), then west to grab the Curse Ball from the hidden chest next to the northern green barrier.

Now head to the event point, and break the white barrier afterwards.

Run along the path north until it turns west. If you act fast, you can grab the treasure chest containing Mai's Hair Ornament to your west along the left wall before the Dark Shadow reaches you. Otherwise, use Rottie's bug skill to jump onto the floating platform and wait till it despawns.

After that, jump back onto the floating platform and head west until you find Life and Death [Entrance] Memo. Read it to get the lock code: 61364.

Use the code to unlock the green barrier, pick up Shina's Glasses, and move on to Brink of Life and Death - Interior.

Brink of Life and Death - Interior
Head past the nearby save point into the room with a number of mobs. The northwest corner is a PC that reveals a false wall and a Curse Ball treasure chest in the northeast corner; the southeast corner is a chest with Ephemeral Flint. Grab the two items and head east through the false wall until you reach a dead end where there's a second Curse Ball to pick up.

Now return to the main room and take the middle path towards the green barrier. Break the white barrier to your right and continue until you reach the room which was behind the green barrier beyond the false wall.

The northwest corner of the room is Al's Hairpin, and on the floating platform is Life and Death Key A • B. This key will let you remove the green barrier to your south, and the green barrier to the north which you ignored earlier to get here.

Head through the green barrier to the north, and jump up the long floating platform. To the south is Clea's Phone, and to the north is a PC that gives you the lock code: 71734.

Use the code on the green barrier left of the PC, and head to the event point.

Keep going after the event, grab Anz Enze in the southwest corner of the room, grab Lucil's Boots in the northeast corner of the room, and then go to the transition zone to Brink of Life and Death - Depths.

Brink of Life and Death - Depths
Head along the path until you spot two PCs. Hack both to reveal a false wall and a hidden treasure chest; be careful of the Dark Shadow that spawns in this narrow space.

Pick up Life and Death Key Z from the hidden chest, and Richt-Ville from the chest next to it.

This key is used in Brink of Life and Death - Interior, so it's time to backtrack there.

Brink of Life and Death - Interior
Return to the room next to the save point and unlock the green barrier to the west.

Follow the path in and head towards the event key item to the north for a Curse Ball, then head back south and break the white barrier to the west which you passed by.

Beyond the white barrier, pick up another Curse Ball where the event key item is, and grab Devil Fang from the northwest corner of the room.

Take the northwest path towards the third event key item (yet another Curse Ball), breaking the white barrier along the way.

Inside this room, Celica's Necklace is around the south wall, and there's a bug skill point nearby that will bring you all the way to the floating platform in the northeast corner. Pick up Life and Death Key • I • II • X • Y from the chest.

You can unlock all the green barriers in this map now, and more importantly, the green barriers back in Brink of Life and Death - Entrance. Time to backtrack some more and head there now.

Brink of Life and Death - Entrance
Return to where you picked up the Curse Ball and head north through the green barrier.

When the path turns west, you'll be given the option to jump up to the floating platform. Don't do that, as there's two treasure chests on the ground containing Martial Master's Bracelet and Demon Ring.

Keep going until you reach a dead end room to the southwest. You can find Lily's Headband in the northeast corner, and Life and Death [Depths] Memo on the floating platform to the southwest corner. Read it to get the code: 12534.

Now you can leave via the east green barrier exit and head back to Brink of Life and Death - Depths.

Brink of Life and Death - Depths
Head down the west corridor with the false wall, and hack the 3 PCs in that square loop to reveal the false walls. There's a Lunaatilk Alma along the west wall of the loop, and a Fairy Bateau along the north wall of the loop.

Leave the square loop from the northwest corner through the false wall, and follow the path until you reach a crossroad that leads west and east.

Head east towards the event key item for a Curse Ball, and then head west from the crossroad.

Pick up Life and Death Key C on the floating platform, and break the white barrier just to your east (the key is redundant, but it opens the green barrier next to where you got the Curse Ball).

Be careful of the Dark Shadow spawns when entering the room. Once you're in, you can find 3 treasure chests along the south wall, they contain an SP Medicine 4.0, Bear Hunter, and an Osiris Balm 2.0. Collect them and use the lock code you got from Life and Death [Depths] Memo to unlock the green barrier to the north.

Save at the save point, and head to the event point when you're ready.

Event Battle:

• True Ending / EX Ending (NG+) Have Rottie & Liliana defeat the 4 Bloody Fly within 5 turns
  
• Fallen Ending Have Rottie & Liliana both die, or fail to kill the 4 Bloody Fly before 5 turns is up

This place is unlocked upon starting NG+, and you can access it by interacting with the phone booth next to the save point at the Women's Dormitory - Center. It's an optional dungeon that acts similar to the Pain Area in the original DER;Q, being a fairly straightforward gauntlet of battles with rewards littered throughout.

One thing to note is that in order to enter the Pain Area, you need to have Mai, Rottie, and Liliana in your party (their Bug Skills are necessary in order to progress, so the game prevents you from entering when they're missing).

Here's a few tips to make the fights easier:

• Lure the enemies away from field bugs so you can space out their buff usage, otherwise knockbacks will destroy them all.
  
• Corner enemies against walls for more bounces.
  
• Learn the timing for Super Knockback & Super Knock Blow to boost your damage.
  
• It's better to stay in Glitched Mode and have higher stats throughout the fight instead of using your burst skill immediately and resetting your corruption %.

Pain Area - Level 1

• Patch 5.0
  
• Ring of the Gods
  
• AR Code Path 2.0
  
• > Lock Code: 49496
  
• Giant's Bracelet
  
• Movil Patron
  
• Pain Area Key A
  
• Copper Flash

Pain Area - Level 2

• Patch 5.0
  
• Expert Ring
  
• AR Code Patch 2.0
  
• Tree's Aura
  
• Pain Area Key B
  
• Brazilocorn
  
• Motal-Makin Alma

Pain Area - Level 3

• SP Medicine 2.0
  
• Moonlight Cannon
  
• Panacea Code
  
• Gale Earrings
  
• AR Code Patch 666.0
  
• Pain Area Key C
  
• God's Bracelet
  
• Shadowbat

Pain Area - Level 4

• SP Medicine 3.0
  
• > Lock Code: 53995
  
• *Pain Area [Level 4] Pass Memo: 39396
  
• Fey Ring
  
• AR Code Patch 666.0
  
• > Lock Code: 46949
  
• Blue Ribbon
  
• SP Medicine 4.0
  
• Symphoza Verze
  
• Osiris Balm 2.0
  
• Pain Area Key D
  
• Hell Hook

Pain Area - Level 5

• SP Medicine 3.0
  
• Panacea Code
  
• > Lock Code: 79993
  
• Life Earrings
  
• AR Code Patch 666.0
  
• > Pain Area [Level 5] Pass Memo: 97641
  
• Prodigy Batara
  
• > Lock Code: 43469
  
• SP Medicine 4.0
  
• Demon Gun Touaha Tasram
  
• Osiris Balm 2.0
  
• Pain Area Key E
  
• Sharulu Sharua

This minigame is also unlocked upon starting NG+, and you can access it by interacting with the phone booth next to the save point at the Women's Dormitory - Center. You don't even need to beat this minigame, as the achievement only requires playing it. But if you're curious about the reward, it's just an accessory called "Ao Oni Earrings" which increases the equipped character's SP by 200. It also can't be claimed again, even on another New Game+ loop (it's like an Episode Chart reward).

A couple of tips for beating the minigame is that the spawn locations of the Oni are always predetermined, only their size and sometimes speed are randomized, so try to remember where they spawn. In addition, you can hide in closets to despawn any Oni that have spawned; but keep in mind they can also open the closet if they're too close when you run inside, so in some cases it might be better to run back towards where you came from to kite the Oni until they despawn (they have a set timer before they go poof).

Here's a crazy fast Ao Oni clear that doesn't even use a closet, as reference...

Unlike the first game, Flash Drive skills in DER;Q2 are unlocked simply by using a specific skill instead of a specific combo. Due to the lack of a visual indicator on which skill you need to use, and the fact that you're not guaranteed to learn them immediately upon use, means it can be hard to figure out what they are if you're unlucky.

Note: Revive-type skills don't need to be cast to learn a skill, simply slotting it into your triact combo will trigger the learning attempt.

All level up skills learned by Lv 53

All level up skills learned by Lv 80

All level up skills learned by Lv 60

All level up skills learned by Lv 60

All level up skills learned by Lv 60

All level up skills learned by Lv 65

All level up skills learned by Lv 60

All level up skills learned by Lv 60

All level up skills learned by Lv 65

Most rewards are just Eni based on the episode's chapter number (100x chapter #, with the Prologue being Chapter 0.5). In addition, some episodes also have mission clear requirements, as well as some being New Game+ (NG+) exclusives.

*Corpse Museum refers to Strain Area, and is how it's written in the original Japanese text (though it's still spoken as Strain Area in Japanese).


Have Rotten & Liliana defeat the 4 Bloody Fly within 5 turns, and then defeat Julietta 2x.

Have Rotten & Liliana lose the fight with the 4 Bloody Fly, then defeat Julietta with Mai alone.

True Ending route on NG+

While not very important beyond getting some decent equipment and consumables during your first playthrough, in NG+, you need to complete specific missions (I'm not sure exactly which ones, so just do them all to be safe) that are made available before the end of each chapter in order to watch the optional episodes listed with "Mission" or "NG+ Mission" in the Episode Chart section (new ones are handed out at the beginning of a chapter).

• Tale of Triumph - Kill X number of enemies
  
• Drop Mission - Farm specific enemies until they drop enough material
  
• Collection Mission - Treasure chest hunting
  
• Shopping Mission - Treasure chest hunting / Purchase from camp shop
  
• Small Boss Mission - Kill miniboss for guarantee drop
  
• Item Collection - Farm enemies that drop Clear Node

The area maps shown below are the finalized version after everything has been unlocked. They may not look the same as your first visit to a location, but as your progress through the game, the map will expand and look like this.

Everything here was compiled and written by me, but I would like to thank the following two resources which were used for cross-referencing and appending extra comments while working on the guide:

• RRPG (JP Resource Guide)[rrpg.jp]
  
• EusisLandale's PS4 Guide[gamefaqs.gamespot.com]