Similar to my high DPS melee build but with a significantly larger and more frequent buffer radius for slowing and defensive measures. Reference guide here: https://psteamcommunity.yuanyoumao.com/sharedfiles/filedetails/?id=2976448867

Focus on

Cell Duplication > Organ Drop Rate > Organ Quality

Secondary

Brain > Base Damage > HP > Critical

Use this room often to review your build.

Aim for rare (blue) or legendary (yellow) quality.
The list is arranged from top to bottom, left to right.
Abbreviation: 2V = 2 vessels

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BRAIN 1 is your main melee DPS source.

• Spine of the Mammoth
  
• Tentacle of the Swordfish
  
• Nerve of the Raptor
  
• Limb of the Skeleton
  
• Retina of the Raven
  
• Limb of the Germ Rat
  
• Nerve of the Boxer
  
• Belly of the Blood Coral
  
• Lung of the Narwhal
  
• Poison Bag of the Wyvern
  
• Spine of the Jackal
  
• Tentacle of the Mushroom

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BRAIN 2 focuses on buffing your damage while accompanying you during movement.

• Lung of the Puffer
  
• Wing of the Giant Bat (2V)
  
• Lung of the Puffer
  
• Lung of the Narwhal
  
• Belly of the Elichu
  
• Belly of the Schrodinger
  
• Intestine of the Camel
  
• Intestine of the Camel
  
• Belly of the Elichu
  
• Wing of the Giant Bat

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BRAIN 3 specializes in slowing down incoming threats while contributing to DPS. It also accompanies you during movement.

• Lung of the Narwhal
  
• Belly of the Yeti (2V)
  
• Intestine of the Camel
  
• Intestine of the Camel
  
• Wing of the Giant Bat (2V)
  
• Belly of the Elichu
  
• Spine of the White Fox
  
• Cochlea of the Cat
  
• Gland of the Monkfish
  
• Tentacle of the Swordfish
  
• Cochlea of the Cat
  
• Tentacle of the Mushroom

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BRAIN 4 primarily focuses on augmenting melee DPS, particularly benefiting Bio-Prototypes with melee critical damage.

• Spine of the Jackal (2V)
  
• Tentacle of the Coral (2V)
  
• Tentacle of the Swordfish
  
• Retina of the Raven
  
• Retina of the Raven (2V)
  
• Retina of the Raven
  
• Limb of the Giant
  
• Tentacle of the Mushroom
  
• Limb of the Skeleton
  
• Limb of the Skeleton
  
• Tentacle of the Worm

Given the complexity of choices involved, this is merely a guide to help you understand HOW to link organs. Feel free to make any desired adjustments.