Head to your preferences in AMD Software

Click on the Cog Icon ----> Preferences


Set all the settings like this


SteamVR Integration = Depends if you are using AMD LINK or not if not the leave it Disabled.
VR Streaming Protocol = Leave it on UDP, its faster. VR Headset, Select the one you have.

In-Game-Overlay = Disabled
Web Browser = Disabled
System Tray Menu = Disabled
Advertisements = Disabled
Toast Notifications = Disabled

Click on the Cog Icon ----> Preferences

Set Use Hotkeys to Disabled

Click on cog wheel icon ---> Graphics



Click on Standard.

Set it to Auto Or Disabled, this messes with a lot of applications. If its forced on in application that has its own sharpening it will crash your driver in most cases and Oculus software.