you unlock your mastery s when you put 100 mushrooms into arrows/lasers i would recommend investing into archers over lasers because lasers take a while to get as good and aren't better into bosses where you can get legendary artifacts

arrows

• good single target dps+ (farming golden artifacts are easier)
  
• spikes early+ (6 archers are cheap)
  
• super crits+
  
• bad wave clear-
  
• single target- (there are healers and range mages)
  
• targeting +

explosives

• good early game wave clear+ (spikes way earlier than lasers good for farming xp/gold)
  
• efficient use of red gems+ (i haven't used this after having tier 3 masteries)
  
• high base dmg+
  
• cant crit- (theoretically falls off later)
  
• bad boss dps-
  
• cant super crit-

lasers

• crits+
  
• good scaling+(6 lasers can bounce)
  
• good wave clear and boss dps+ (lvl800 lasers, lvl 49 powergem, lvl100 platinum ring, lvl 25 rubber eye, and 100k hp soloed the last boss cave)
  
• spikes late- (spikes at lvl 301)
  
• garbage early game- (important upgrades are too expensive)
  
• cant super crit-

do your local save every time your online
early get the research upgrades to help progression
buying power gems are good early
if your going to close the app invest in offline with gems
buy auto merge tier 1 and inventory slots instead of tier 2 (if you afk)
accessory slots are op

don't sell any accessory its better to max it out and filter it our with ITEM FILTER under the trash
exp>gold always
another reason why arrows are better than lasers early is the 2nd boss cave drops diamond arrows and the 3rd boss drops rubber eye
most of the rings are bad except platinum you can use emerald and gold to farm a stage when afk
bronze ring might be lowkey good as filler for hard stages because lvl 100 gives 40 percent hp but lightning shield gives 25+

3rd slot legendary artifact of your main weapon
another reason why arrows are good is in the second area it drops a arrow buff for torch slot that give crit dmg and armor pen
the rest of the accesory so far have been shields (im at mounatain 2000)

area 1 purple = plat ring (all dmg bonus)
area 2 purple = radius torch (bigger explosions size)
area 3 purple = blocking shield (chance to block attack)
area 4 purple = emerald ring (xp)