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I actually used that type of build to determine how much HP each monster had to write this guide (You can't over-heal the monster's max HP, so it'll always be accurate).
I can't say I'd recommend a basic-attack build for the True Final Boss, though.
Head: Saint's Ribbon (Nullifies all ailments, with some exceptions )
Accessory 1: Sea Monster Emblem (strikes twice, even when the first strike is a Miss)
Accessory 2: Harvest Emblem (drains HP from the enemy with regular attack, magic doesn't count).
Only Paracess Antithesis, the True Final Boss, forced me to use Health potions and/or Healing skills. Ok, you must be able to beat the Kraken and the Grim Reaper, but I guess it is much sooner than the build you propose.
I never found out myself until I was writing this guide (since my first time fighting him I missed the Forgotten Treasure House, thinking it wasn't available for a Pure-Run [which it is, just be careful about picking up the tentacle suit from the chest]).
It truly helps a lot within the fight. ... And I don't think it shows as much usefulness anywhere else (since it isn't needed as much as this superboss).
the fight took overall 45 minutes
I didn't even think to use poison on Nuxy. I'll add it to the guide section, thanks!
You actually just need the skill to "collect" it regardless of its source.
At some point in your Lewd-activities, you'll start being given daily offerings of white-fluid, so you don't even have to go out to get it at that point (in the same area of your church where you pick up daily offerings each day [which generally contains consumable items]).