This is a small guide for players like me that had dificult to use/figure out the lock on system for PC setting.

1- In the options turn off the auto lock on for crates.
2- Set at the keybind options an easy to use button for the lock on.
3- At the beginning of the battle turn off the lock on for freedom of movement.
4- Whenever you turn on the lock on, ONLY move the mouse if you wish to change targets. As long you dont move the mouse the current target will be kept.
5- Turn off lock on whenever you need to run, move.

Thats it. Have a good game.