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Holy ray is not as useful compared to invulnerability. Everyone seems to use it but don't realise that when it counts, you need invulnerability (reviving allies/real missiles/mines/bloody well everything) and the healing from Holy ray is subpar considering you can't take ray of awesome with it.
Buffer is also not really that useful. If you're going mage, you should be invulning people. Extra damage is not necessary for gunner.
Defender should take Never Surrender as he's going to be alive much more than rogue or mage. Barring that he should take taunt to make use of his high blocking capability. Defender shouldn't be trying to do high damage.
I might suggest Backpack and/or Alchemist for the Backstabber + Shadow Run strategy you have for the rogue. Alchemist as an additional option for the Gunner + Violent + Shadow Run +Backpack, too.
I'm not 100% sure whether or not Melee attacks are affected by elemental combos.