Stroggification is a colloquialism that quickly became official medical terminology to refer to the process of an unwilling human victim undergoing advanced Strogg cybernetic augmentation and thereby being transformed into a Strogg soldier. The Quake 4 manual describes it much simpler as "in a brutal surgical process, the limbs and flesh of the fallen are fused with metal and machinery to create the monstrosities that are the alien Strogg". In a broader sense it can therefore mean the process of creating any Strogg, which is the only method of Strogg procreation, which is achieved using mechanical parts and harvested biological components, usually from unwilling or dead donors. It is possible that the Strogg also clone bodies specifically for this purpose, genetically engineered and subsequently stroggified for maximum combat performance.

It is notable that the Strogg seem to be able to assemble units even from dead body parts. This requires highly advanced medical technology that is capable of reanimating dead tissue and also of controlling its biological functions.

Apart from "standard" Stroggification, the Strogg sometimes take subjects to experimental Stroggification sites where prototypes of potential new Strogg units are developed. The only known human who underwent this procedure is Lt. Voss of Rhino Squad.

Although Stroggification can mean the general act of creating a new Strogg, it most famously refers to the process applied to captive marines to create the Tactical Class Strogg. This famously was undergone, and survived by a very lucky Corporal Matthew Kane, whose newly acquired Strogg physiology proved to be invaluable to the human war effort in the Second Invasion of Stroggos.